Providence Heart and Vascular Institute - eCardioVascular Beat

Enrollment criteria

Subjects with PFO who have had a "cryptogenic stroke" within the last 270 days. Call for more specific inclusion/exclusion criteria.

Principal investigator

Todd Caulfield, M.D.

Sponsor

AGA Medical Corp.

Contact

Eric Johnson, C.C.R.C., clinical research supervisor, 503-216-2075

Principal investigator

Todd Caulfield, M.D.

Occluder sponsor

AGA Medical Corp.

Contact

Eric Johnson, C.C.R.C., clinical research supervisor, 503-216-2075

Inclusion criteria

• Patients with one or two de novo lesions each in a different epicardial vessel
• Must have TIMI flow of 1 and diameter stenosis =50% and <100%

Exclusion criteria

• MI with enzymes still elevated
• LVEF <30%
• TIA/CVA in past 6 months
• On chronic anticoagulation therapy (Coumadin or heparin)

Principal investigator

Todd Caulfield, M.D.

Sponsor

Abbott Vascular

Contact

Ellen Muir, clinical research coordinator, 503-216-2110

Enrollment criteria

Patients undergoing PCI with either DES or BMS without known contraindication to dual antiplatelet therapy for at least 30 months after enrollment and stent implantation

Principal investigator

Todd Caulfield, M.D.

Sponsor

Harvard Clinical Research Institute (HCRI)

Contact

Maile Barrett, clinical research coordinator, 503-216-2099

This is a study of an investigational device called the DexCom™ IVBG sensor. The DexCom™ IVBG sensor is a device that measures blood glucose through a dedicated IV site. The device can measure blood sugar levels every 7 minutes.

Principal investigator

Anthony Furnary, M.D.

Sponsor

Edwards Lifesciences LLC, DexCom Inc.

Contact

Maile Barrett, clinical research coordinator, 503-216-2099

Principal investigator

Anthony Furnary, M.D.

Sponsor

Providence Heart and Vascular Institute with funding from Sanofi-Aventis and LifeScan Inc.

Contact

Eric Johnson, C.C.R.C., clinical research supervisor, 503-216-2075

Inclusion criteria

• Patient is between ages of 18 to 80 years old
• Documented longstanding persistent Afib OR non self-terminating Afib
• Patient scheduled for concomitant cardiac procedure

Exclusion criteria

• EF <30%
• History of Afib >10 years
• Left atrial size >6.0

Principal investigator

E. Charles Douville, M.D.

Sponsor

nContact Surgical Inc.

Contact

Michelle Dixon, C.C.R.C., clinical research coordinator, 503-215-6746

Inclusion criteria

• Patient is scheduled to receive ON-X mechanical valve (aortic or mitral)
• Concomitant cardiac surgery IS allowed

Exclusion criteria

• Double (aortic and mitral) valve REPLACEMENT
• Patients with ACTIVE endocarditis
• Previous thromboembolic event within last year

Principal investigator

E. Charles Douville, M.D.

Sponsor

On-X/MCRI

Contact

Michelle Dixon, C.C.R.C., clinical research coordinator, 503-215-6746

Inclusion criteria

• Have documented AF episodes >2 episodes over 4 months with electrocardiographic documentation of 1 episode or at least 1 episode of AF lasting more than 1 week
• Warrant active therapy beyond simple ongoing observation
• Be eligible for catheter ablation and >2 sequential rhythm control and/or >3 rate control drugs
• Be >65 years of age, or <65 years with one or more of the following risk factors for stroke: hypertension, diabetes, congestive heart failure (including systolic or diastolic heart failure), prior stroke or TIA, LA size >5.0cm (or volume index >44cc/m2) or EF<35. Subjects <65 years of age whose only risk factor is hypertension must have a second risk factor or LV hypertrophy to qualify

Exclusion criteria

• Lone AF in absence of risk factors for stroke in patients <65 years of age
• Patients who in the opinion of managing clinician should not yet receive any therapy for AF
• Patients who have failed >2 membrane active anti-arrhythmic drugs at a therapeutic dose due to inefficacy or side effects
• More than 1 week of amiodarone treatment in the past 3 months
• An efficacy failure of full-dose amiodarone treatment >12 weeks duration at any time

Principal investigator

Blair Halperin, M.D.

Sponsor

National Heart Lung and Blood Institute (NHLBI)

Contact

Maile Barrett, clinical research coordinator, 503-216-2099

Inclusion criteria

• Presence of typical atrial flutter (cavotricuspid isthmus dependent)
• If subjects receiving antiarrhythmic drug therapy (Class I or Class III AAD) for arrhythmia other than typical atrial flutter, then the subject needs to be controlled on their medication for at least 3 months. If the subject had typical atrial flutter before starting the AAD(s) (Class I or Class III) and subsequently had another arrhythmia (i.e. Atrial Fibrillation), then the 3-month AAD criteria will not apply.
• One documented occurrence of the study arrhythmia documented by ECG, Holter, telemetry strip, or transtelephonic monitor within the past 6 months.

Exclusion criteria

• Prior typical atrial flutter ablation treatment
• Atypical flutter or scar flutter (non-isthmus dependent)
• Significant coronary heart disease or heart failure; that is unstable angina pectoris and/or uncontrolled congestive heart failure (NHYA Class III or IV) at the time of enrollment
• A recent MI within 3 months of the intended procedure date
• Permanent coronary sinus pacing lead

Principal investigator

D. Randolph Jones, M.D.

Sponsor

St. Jude Medical Inc.

Contact

Maile Barrett, clinical research coordinator, 503-216-2099

Inclusion criteria

• Patients with CHF for >3 months, and NYHA class II, III, or IV
• EF <40%
• Hemoglobin must be between: 9.0 g/dL-12.0 g/dL

Exclusion criteria

• B12 or Folate below lower limit of normal
• Tsat is <15%
• CHF is primarily due to valvular disease

Principal investigator

Ranae Ratkovec, M.D.

Sponsor

Amgen Pharmaceuticals

Contact

Michelle Dixon, C.C.R.C., clinical research coordinator, 503-215-6746

Inclusion criteria

• Patients with CHF (new or previous)
• EF >45%
• BNP >100 pg/ml OR hospitalized in last 12 months with CHF

Exclusion criteria

• Serum Potassium >5.0 mmol/L
• MI in past 90 days
• Significant chronic pulmonary disease

Principal investigator

Ranae Ratkovec, M.D.

Sponsor

National Heart, Lung and Blood Institute, which is part of the NIH

Contact

Michelle Dixon, C.C.R.C., clinical research coordinator, 503-215-6746

Enrollment criteria

• Symptomatic patients with >50% carotid artery stenosis OR
• Asymptomatic patients with >80% carotid artery stenosis AND
• One or more of the following risk factors:
• • Congestive heart failure and/or known severe left ventricular dysfunction LVEF <35%
  • Open-heart surgery within six weeks
  • Recent MI (>24 hours and <6 weeks)
  • Unstable angina
  • Synchronous severe cardiac and carotid disease requiring open heart surgery and carotid revascularization
  • Requirement for simultaneous or staged cardiac valve surgery, peripheral vascular surgery, or AAA repair within 60 days
  • Severe pulmonary disease
  • Contralateral carotid occlusion
  • Contralateral laryngeal palsy
  • Post-radiation treatment to the neck
  • Previous CEA recurrent stenosis
  • High cervical ICA lesions or CCA lesions below the clavicle
  • Severe tandem lesions
  • Abnormal stress test

Principal investigator

Brad Evans, M.D.

Contact

Cindy Payne, L.P.N., cardiovascular research coordinator, The Oregon Clinic; 503-963-2946

The CAPTURE-2 Post Market Study is an observational study to collect safety data on patients receiving carotid stents. Patients will be administered a brief neurologic exam (NIH Stroke Scale) before their carotid procedure, 24-hour post-procedure, and at a 30-day office visit.

Enrollment criteria

• Symptomatic patients with >50% carotid artery stenosis OR
• Asymptomatic patients with >80% carotid artery stenosis

Principal investigator

Brad Evans, M.D.

Contact

Cindy Payne, L.P.N., cardiovascular research coordinator, The Oregon Clinic; 503-963-2946

Principal investigator

Naveen Sachdev, M.D.

Sponsor

AngioDynamics

Contact

Eric Johnson, C.C.R.C., clinical research supervisor, 503-216-2075

Investigators

John Roll, M.D., Todd Kuether, M.D.

Device sponsor/manufacturer

Cordis Neurovascular Inc.

Contact

Eric Johnson, C.C.R.C., clinical research supervisor, 503-216-2075

Principal investigator

Kenton Gregory, M.D.

Sponsor

Oregon Medical Laser Center

Contact

Eric Johnson, C.C.R.C., clinical research supervisor, 503-216-2075

Principal investigator

Brad Evans, M.D.

Sponsor

Cardiovascular Research Foundation

Principal investigator

Todd Caulfield, M.D.

Sponsor

Boston Scientific Corp.

Principal investigator

Todd Caulfield, M.D.

Sponsor

Boston Scientific Corp.

Principal investigator

Todd Caulfield, M.D.

Sponsor

Guidant Corp./Abbott Vascular Inc.

Principal investigator

Todd Caulfield, M.D.

Sponsor

Abbott Vascular Inc.

Principal investigators

Jeffrey Swanson, M.D., E. Charles Douville, M.D.

Sponsor

St. Jude Medical S.C., Inc.

Principal investigator

Jeffrey Swanson, M.D.